Irresistible Spicy Southern Chicken Spaghetti Casserole

Name: Irresistible Spicy Southern Chicken Spaghetti Casserole
Prep time: 20 min
Cook time: 40 min
Total time: 1 h
Yield: 6 servings
Ingredients: 2 cups cooked chicken, shredded; 8 ounces spaghetti; 1 can (10.5 ounces) cream of chicken soup; 1 cup sour cream; 1 cup shredded cheddar cheese; 1/2 cup diced tomatoes with green chilies; 1 tablespoon olive oil; 1 teaspoon paprika; 1 teaspoon garlic powder; 1 teaspoon onion powder; Salt and pepper to taste; Chopped green onions for garnish

Highlighted under: Comfort Food

Savor the delightful combination of tender chicken, zesty spices, and creamy pasta in this Irresistible Spicy Southern Chicken Spaghetti Casserole. This comforting dish is perfect for family dinners or potlucks, offering a warm and hearty meal that everyone will love. With a kick of spice and a blend of Southern flavors, your taste buds will dance with joy!

Created by

Heidi Lawson

Last updated on 2025-12-13T06:29:52.875Z

This dish is inspired by Southern home cooking traditions, combining everyday ingredients with a delightful kick of spice.

        Why You'll Love This Recipe
        Perfect for family gatherings or potlucks.
A delicious way to use leftover chicken.
Creamy and spicy, it's a unique twist on classic spaghetti.

      

Flavorful Ingredients that Shine

One of the standout features of this Irresistible Spicy Southern Chicken Spaghetti Casserole is its flavorful ingredient palette. Each component plays a vital role in creating a delicious harmony of tastes. The combination of creamy soups and sour cream adds a rich, velvety texture, while shredded chicken brings a satisfying heartiness to the dish. Using diced tomatoes with green chilies introduces a delightful kick that complements the spices perfectly.

Don’t underestimate the importance of spices in any Southern dish. The blend of paprika, garlic powder, and onion powder doesn’t just enhance the flavors; it elevates the entire meal to a new level. Each bite bursts with savory goodness, making this casserole more than just a comforting meal; it's an experience that will leave everyone craving more.

A Comforting Meal for Any Occasion

Whether you’re hosting a family gathering or need to whip up a dish for a potluck, this casserole checks all the boxes. It can be prepared ahead of time and baked just before serving, making it incredibly convenient for busy schedules. The ease of meal prep means you can spend less time in the kitchen and more time enjoying the company of loved ones.

Moreover, the comforting nature of this dish is second to none. With its creamy texture and enticing spices, it’s perfect for everything from family dinners to casual get-togethers. Your guests will appreciate the warmth and hospitality that comes with a home-cooked meal, and you can take pride in serving something that’s both hearty and satisfying.

Tips for Perfecting Your Casserole

Ingredients

Gather the following ingredients to make this delicious casserole:

Ingredients

2 cups cooked chicken, shredded
8 ounces spaghetti
1 can (10.5 ounces) cream of chicken soup
1 cup sour cream
1 cup shredded cheddar cheese
1/2 cup diced tomatoes with green chilies
1 tablespoon olive oil
1 teaspoon paprika
1 teaspoon garlic powder
1 teaspoon onion powder
Salt and pepper to taste
Chopped green onions for garnish

Make sure all ingredients are fresh for the best flavor.

Instructions

Follow these steps to create your casserole:

Preheat the oven

Preheat your oven to 350°F (175°C).

Cook the spaghetti

In a large pot, cook spaghetti according to package instructions. Drain and set aside.

Prepare the mixture

In a large bowl, combine shredded chicken, cream of chicken soup, sour cream, diced tomatoes, cheddar cheese, olive oil, paprika, garlic powder, onion powder, salt, and pepper.

Combine ingredients

Add the cooked spaghetti to the chicken mixture and stir to combine.

Transfer to baking dish

Transfer the mixture to a greased 9x13 inch baking dish, spreading it evenly.

Bake

Bake in the preheated oven for about 30 minutes, or until bubbly and golden on top.

Serve

Let it cool for a few minutes before serving. Garnish with chopped green onions.

Enjoy your hearty and flavorful casserole!

The Perfect Pairings

When serving your Irresistible Spicy Southern Chicken Spaghetti Casserole, consider complementary side dishes to enhance the overall dining experience. A light green salad with a zesty vinaigrette can balance the richness of the casserole. Additionally, cornbread or garlic bread will add a comforting touch that everyone will enjoy.

For a full Southern experience, pair your casserole with sweet tea or lemonade. These refreshing beverages complement the spice in the dish while providing a satisfying contrast that rounds out your meal perfectly.

Storage and Leftover Ideas

Storing leftovers is simple with this casserole. Once cooled, it can be covered and kept in the refrigerator for up to three days. When reheating, simply pop it back into the oven at 350°F (175°C) until it's heated through, or use the microwave for a quick warm-up. The flavors meld beautifully during storage, often making the leftovers even more delicious!

If you ever find yourself with more casserole than you can eat, consider freezing it. Portion the casserole into airtight containers or freezer bags, and you'll have ready-made meals for those busy days ahead. Just be sure to thaw in the refrigerator overnight before reheating for the best results.

Questions About Recipes

→ Can I use other types of cheese?

Yes! You can substitute cheddar with mozzarella or pepper jack for different flavors.

→ Can I make this casserole ahead of time?

Absolutely! Prepare it, cover, and refrigerate. Bake it when ready to serve.